BUFFALO, N.Y.—A Polygonum cuspidatum extract (PCE)-containing resveratrol had a comprehensive suppressive effect on oxidative and inflammatory stress, according to a study published in the Journal of Clinical Endocrinology & Metabolism (June 9, 2010). Two groups of 10 normal-weight healthy subjects were randomized to placebo or PCE containing 40 mg/d of resveratrol for six weeks. Fasting blood samples were obtained prior to and after treatment at one, three and six weeks. Indices of oxidative and inflammatory stress, suppressor of cytokine signaling-3, phosphotyrosine phosphatase-1B, jun-N-terminal kinase-1 and inhibitor of kappaB-kinase-beta were measured by RT-PCR and Western blotting.
The extract induced a significant reduction in reactive oxygen species generation, the expression of p47phox, intranuclear nuclear factor-B binding and the expression of jun-N-terminal kinase-1, inhibitor of B-kinase-beta, phosphotyrosine phosphatase-1B and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6 and C-reactive protein. There was no change in these indices in the control group given placebo.